IN VIVO ELIMINATION OF ARSENIC THROUGH LACTOBACILLUS SPOROGENES.

Groundwater arsenic contamination is a global phenomenon affecting more than 70 countries on six continents. Arsenic is one of the more ubiquitous minerals in the Earth’s crust. It is also concentrated in hydrous iron oxides. Arsenic can be easily solubilized in ground waters depending on pH, redox conditions, temperature and solution composition. Therefore the study is designed to evaluate in vivo effect of Lactobacillus sporogenes on arsenic degradation in mice. Mice were administered arsenic for four weeks followed by 8 weeks administration of Lactobacillus. Arsenic causes increased level of urea and uric acid. While urea and uric acid level were restored effectively in Lactobacillus administered group. Glomerulus and Bowmens capsule were restored effectively in eight weeks Lactobacillus administered group. Cytoplasm of PCT and DCT were restored effectively after eight weeks of Lactobacillus administration. Therefore it is concluded that Lactobacillus causes in vivo elimination of arsenic from mice. It acts well against arsenic induced toxicity in mice and restores biochemical parameters effectively. It also maintains normal morphology of kidney tissues. Lactobacillus reduces nephrotoxicity caused by arsenic exposure effectively. In this way it acts effectively against arsenic induced toxicity. Therefore it is one of the most effective antidote against arsenic induced toxicity.